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Clear-cell adenocarcinoma of the vagina
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Clear-cell adenocarcinoma of the vagina : ウィキペディア英語版
Clear-cell adenocarcinoma of the vagina

Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol (DES), a drug which was prescribed in the mistaken belief that it prevented miscarriage and ensured a healthy pregnancy.
==History==
The synthetic estrogen DES was given to millions of pregnant women in the United States and other countries. Use in the US was primarily from 1938-1971 but not limited to those years. Internationally, DES use continued until the early 1980s. DES was given if a woman had a previous miscarriage, diabetes, or a problem-pregnancy with bleeding, threatened miscarriage or premature labor.
Up until the mid to late 1950s some women were given DES shots. After that, DES was primarily prescribed in pill form. DES also was included in some prenatal vitamins.
In the late 1960s through 1971 a cluster of young women, from their teens into their twenties, was mysteriously diagnosed with CCA, a cancer not generally found in women until after menopause. Doctors at Massachusetts General Hospital in Boston eventually linked DES exposure before birth to the development of CCA in these young woman. They determined the risk for developing CCA among so-called DES Daughters is small, estimated at 1 in a 1,000.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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